Gold is a scarce resource in Baldur's Gate 3 and the game does a great job of making sure players have enough to play around with but not so much that they can eventually guy the best of everything for every character. That means players should be picking up and selling about everything that isn't nailed down.
Baldur's Gate 3: How To Manage Encumbrance
Nothing ruins the momentum in Baldur's Gate 3 quite like becoming encumbered after getting weighed down by loot in the middle of a dungeon.